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  • Title: Diazepam treatment does not influence the debrisoquine or mephenytoin hydroxylation phenotyping tests.
    Author: Spina E, Buemi AL, Sanz E, Bertilsson L.
    Journal: Ther Drug Monit; 1989 Nov; 11(6):721-3. PubMed ID: 2595755.
    Abstract:
    Debrisoquine and S-mephenytoin hydroxylation phenotyping tests were performed in 9 patients before and during treatment with diazepam at a daily dose of 10 or 15 mg. There was no change in either the debrisoquine/4-hydroxydebrisoquine ratio or the ratio of S/R mephenytoin in urine. The hydroxylation of these two test drugs is apparently not inhibited by administration of therapeutic doses of diazepam.
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