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  • Title: Vitamin D Deficiency and Critical Illness.
    Author: Prasad S, Raj D, Warsi S, Chowdhary S.
    Journal: Indian J Pediatr; 2015 Nov; 82(11):991-5. PubMed ID: 25967259.
    Abstract:
    OBJECTIVE: To determine the prevalence of vitamin D deficiency in critically ill children and assess its association with severity of illness and other outcomes associated with critical illness. METHODS: Eighty children aged 2 mo to 12 y, admitted with medical conditions to the pediatric intensive care unit of a tertiary care hospital were enrolled in this prospective observational study. Vitamin D levels were obtained during the first hour of stay. Severity score was assessed using the Pediatric Risk of Mortality III (PRISM III) within first 12 h of admission. RESULTS: Vitamin D deficiency {25-hydroxy vitamin D [25(OH)D] levels < 20 ng/ml} was observed in 67 (83.8%) children. Vitamin D deficient children had significantly higher PRISM III score compared to vitamin D sufficient children [10 (IQR:5-15) vs. 6 (IQR:3-7); p 0.0099]. 25(OH)D levels had a significant negative correlation with PRISM III score (ρ -0.3747; p 0.0006). CONCLUSIONS: Vitamin D appears to be of utmost importance in critically ill children.
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