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  • Title: Residential radon and lung cancer characteristics in never smokers.
    Author: Torres-Durán M, Ruano-Ravina A, Parente-Lamelas I, Leiro-Fernández V, Abal-Arca J, Montero-Martínez C, Pena-Álvarez C, Castro-Añón O, Golpe-Gómez A, Martínez C, Guzmán-Taveras R, Mejuto-Martí MJ, Provencio M, Fernández-Villar A, Barros-Dios JM.
    Journal: Int J Radiat Biol; 2015 Aug; 91(8):605-10. PubMed ID: 25968558.
    Abstract:
    PURPOSE: The aim of this study is to assess if there is a relationship between residential radon and lung cancer histological types and patients' age at diagnosis. MATERIALS AND METHODS: We conducted a multicenter hospital-based case-control study with eight participating hospitals. We included 216 never-smoking cases with primary lung cancer and 329 never-smoking controls. Controls were frequency matched with cases on age and sex distribution. Of them, 198 cases (91.7%) and 275 controls (83.5%) had residential radon measurements. RESULTS: Lung cancer risk reached statistical significance only for adenocarcinoma (Odds ratio [OR] 2.19; 95% Confidence interval [CI] 1.44-3.33), for other histologies the results were marginally significant. Residential radon level was higher for patients diagnosed before 50 and 60 years old than for older lung cancer cases. CONCLUSIONS: Residential radon in never smokers seems to be a risk factor for all lung cancer histologies. Individuals diagnosed at a younger age have a higher residential radon concentration, suggesting an accumulative effect on lung cancer appearance.
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