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Title: NADH- and NADPH-linked aquacobalamin reductases occur in both mitochondrial and microsomal membranes of rat liver. Author: Watanabe F, Nakano Y, Maruno S, Tachikake N, Tamura Y, Kitaoka S. Journal: Biochem Biophys Res Commun; 1989 Dec 15; 165(2):675-9. PubMed ID: 2597154. Abstract: To elucidate the mechanism for the synthesis of the coenzyme forms of cobalamin in mammals, rat liver aquacobalamin reductase was partially characterized. Rat liver contained both NADH- and NADPH-linked aquacobalamin reductases. The NADH-linked enzyme was distributed in the mitochondria (approx. 40%) and microsomes (60%), identical to the distribution of the NADPH-linked enzyme. The two mitochondrial NADH- and NADPH-linked enzymes were located inside of the outer membrane.[Abstract] [Full Text] [Related] [New Search]