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  • Title: Penicillin allergy: A practical guide for clinicians.
    Author: Gonzalez-Estrada A, Radojicic C.
    Journal: Cleve Clin J Med; 2015 May; 82(5):295-300. PubMed ID: 25973877.
    Abstract:
    Penicillin allergy is the most commonly reported drug allergy in the United States. However, after undergoing a complete evaluation by a board-certified allergist, including skin testing, 90% of patients labeled as 'penicillin-allergic' are able to tolerate penicillin. Clinical presentation is key in classifying reactions as either mediated by or not mediated by immunoglobulin E (IgE), and in determining which patients may benefit from penicillin skin testing, graded-dose challenge, or desensitization. Cross-reactivity between penicillin and other beta-lactams is less common than previously thought.
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