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  • Title: Plasma N-terminal pro-B-type natriuretic peptide concentration in healthy retired racing Greyhounds.
    Author: Couto KM, Iazbik MC, Marín LM, Zaldivar-López S, Beal MJ, Gómez Ochoa P, Couto CG.
    Journal: Vet Clin Pathol; 2015 Sep; 44(3):405-9. PubMed ID: 25982692.
    Abstract:
    BACKGROUND: N-terminal pro-B-type natriuretic peptide (NT-proBNP) is a cardiac biomarker whose plasma concentration is high in some dogs with cardiopulmonary disease. NT-proBNP is a diagnostic tool that can be used to help determine if a patient has congestive heart failure. Greyhounds have functional heart murmurs, relative cardiomegaly, and high serum cTnI concentration. OBJECTIVES: The purpose of the study was to evaluate the plasma concentration of NT-proBNP in healthy Greyhounds and compare it to non-Greyhound dogs. METHODS: We prospectively evaluated healthy client-owned dogs including retired racing Greyhounds and non-Greyhounds. Plasma was obtained and transferred into tubes containing a protease inhibitor and submitted for a specific NT-proBNP ELISA assay. RESULTS: The plasma NT-proBNP concentration in Greyhounds was significantly higher than in non-Greyhound control dogs (946 vs 632 pmol/L; P < .005); 46% of Greyhounds had NT-proBNP > 1000 pmol/L. CONCLUSIONS: Plasma NT-proBNP concentration in Greyhounds is high and should be interpreted with caution.
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