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  • Title: [The influence of ciprofloxacin and pefloxacin on blood coagulation and the anticoagulant effect of heparin].
    Author: Lepakhin VK, Ushkalova EA, Shcheglova NV.
    Journal: Farmakol Toksikol; 1989; 52(5):33-6. PubMed ID: 2599074.
    Abstract:
    At a single intravenous administration to rabbits ciprofloxacin (10 and 20 mg/kg) and pefloxacin (40 mg/kg) increased the blood coagulability. Administered in a dose of 20 mg/kg pefloxacin exerted no effect on the parameter. Ciprofloxacin (20 mg/kg) and pefloxacin (40 mg/kg) decreased the anticoagulant effect of heparin (100 U/kg).
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