These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The antihypoxic activity of endogenous cyclic derivatives of gamma-aminobutyric acid].
    Author: Mirzoian SA, Ekavian AG, Balasanian MG, Topchian AV.
    Journal: Farmakol Toksikol; 1989; 52(5):41-3. PubMed ID: 2599076.
    Abstract:
    Pirrolidone-2, gamma-butyrolacton, succinic anhydride were found to possess pronounced antihypoxic activity that manifested itself in their ability to decrease the level of lactic acid accumulated during hypoxia. Pirrolidone-2 and succinic anhydride increase succinic dehydrogenase activity in vitro. At intraperitoneal administration the above mentioned compounds lead to lactate dehydrogenase activity inhibition under normal conditions while during circulatory hypoxia they stimulate lactate dehydrogenase reaction promoting the maintenance of energy balance of the cerebral tissue at the appropriate level.
    [Abstract] [Full Text] [Related] [New Search]