These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [The pharmacokinetics and the concentration-and-effect relationship of prazosin in patients at the beginning of the subacute period of myocardial infarct complicated by the development of heart failure].
    Author: Ol'binskaia LI, Petrosian IuR, Gofman AM.
    Journal: Farmakol Toksikol; 1989; 52(5):68-72. PubMed ID: 2599083.
    Abstract:
    The pharmacokinetics of prazosin was studied in 16 patients in the early subacute period of myocardial infarction complicated with heart failure following a single and 10-day administration. The increase of the half-life of the drug (6.6 +/- 1.6 h) and the elevation of the blood plasma concentration 1-2.5 h after administration (87 +/- 33 ng/ml) were found. After 10-day administration the increase of the apparent total clearance of the drug was established. The blood plasma levels of prazosin significantly correlated with the change of the hemodynamic parameters measured invasively after a single administration of 2-5 mg of the drug. After 10 days of treatment the correlation weakened and the regression line angle reduced that reflected the development of tolerance to the drug. On the basis of the calculated effective concentrations, there were determined the optimal intervals of the drug dosage.
    [Abstract] [Full Text] [Related] [New Search]