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  • Title: Age-related changes in lipid peroxidation and protective enzymes in the central nervous system.
    Author: Ansari KA, Kaplan E, Shoeman D.
    Journal: Growth Dev Aging; 1989; 53(3):117-21. PubMed ID: 2599741.
    Abstract:
    Brain homogenates were used to measure in vitro formation of thiobarbituric acid reactive substances (TBARS) in 5 CNS regions of 3, 12 and 22 month old male Fischer 344 rats. Glutathione peroxidase, catalase and superoxide dismutase activity in 105,000 x g supernatants of these homogenates was also measured. Results indicated that in vitro TBARS formation declined with age in all 5 areas studied. Glutathione peroxidase, catalase and superoxide dismutase activity did not change with age. Regional differences in the activity of glutathione peroxidase and catalase were noted.
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