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  • Title: Hb Fontainebleau [alpha 21(B2)Ala----pro], a new silent mutant hemoglobin.
    Author: Wajcman H, Blouquit Y, Gombaud-Saintonge G, Riou J, Galacteros F.
    Journal: Hemoglobin; 1989; 13(5):421-8. PubMed ID: 2599878.
    Abstract:
    Hb Fontainebleau [alpha 21(B2)Ala----Pro] was found in a family of Italian origin. This new variant has electrophoretic properties identical to those of Hb A with the exception of isoelectrofocusing in which it migrates like Hb A1c. The introduction of a prolyl residue at the beginning of the B helix in the alpha chain does not lead to a change in the stability or oxygen binding properties of the hemoglobin molecule.
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