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  • Title: MicroRNA-130a Targets MAP3K12 to Modulate Diabetic Endothelial Progenitor Cell Function.
    Author: Ye M, Li D, Yang J, Xie J, Yu F, Ma Y, Zhu X, Zhao J, Lv Z.
    Journal: Cell Physiol Biochem; 2015; 36(2):712-26. PubMed ID: 25999017.
    Abstract:
    AIMS: The aim of the present study was to explore the influence of microRNA (miR)-130a dysregulation on the JNK signal pathway through its target MAP3K12 in diabetic endothelial progenitor cells (EPCs). METHODS: The expression of miR-130a was compared between diabetic and normal EPCs. Computational target prediction was performed to identify MAP3K12 as a functionally relevant target of miR-130a in EPCs. The role of miR-130a was investigated regarding its anti-apoptotic effects and its role on the regulation of EPC function was evaluated through the negative regulation of the JNK signal pathway RESULTS: MiR-130a expression was significantly downregulated in diabetic EPCs, and cell proliferation was reduced in EPCs under high glucose condition. miR-130a inhibited the JNK pathway by targeting MAP3K12, contributing to its anti-apoptotic effect and the maintenance of EPC function. In diabetic EPCs, high glucose affects the expression of miR-130a, inducing sustained JNK activation and promoting EPC apoptosis and dysfunction. CONCLUSIONS: Downregulation of miR-130a may underlie endothelial dysfunction in diabetes through the activation of JNK signal pathway.
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