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  • Title: Proline-rich AKT substrate of 40-kDa (PRAS40) in the pathophysiology of cancer.
    Author: Malla R, Ashby CR, Narayanan NK, Narayanan B, Faridi JS, Tiwari AK.
    Journal: Biochem Biophys Res Commun; 2015 Jul 31; 463(3):161-6. PubMed ID: 26003731.
    Abstract:
    Dysregulation of PI3K-AKT-mTOR pathway has been reported in various pathologies, such as cancer and insulin resistance. The proline-rich AKT substrate of 40-kDa (PRAS40), also known as AKT substrate 1 (AKT1S1), lies at the crossroads of these cascades and inhibits the activity of the mTOR complex 1 (mTORC1) kinase. This review discusses the role of PRAS40 and possible feedback mechanisms, and alterations in AKT/PRAS40/mTOR signaling that have been implicated in the pathogenesis of tumor progression. Additionally, we probed new datasets extracted from Oncomine, a cancer microarray database containing datasets derived from patient samples, to further understand the role of PRAS40 (AKT1S1). These data strongly supports the hypothesis that PRAS40 may serve as a potential therapeutic target for various cancers.
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