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  • Title: Evaluation of blood volume by use of blood oxygen level-dependent magnetic resonance imaging in a cuff-compression model: usefulness of calculated echo time image.
    Author: Nishii T, Kono AK, Nishio M, Kyotani K, Nishiyama K, Sugimura K.
    Journal: Jpn J Radiol; 2015 Jul; 33(7):441-7. PubMed ID: 26006707.
    Abstract:
    PURPOSE: Separate assessment of changes in blood oxygenation and blood volume is required in blood oxygen level-dependent (BOLD) imaging. We developed a calculated echo time (TE) imaging technique designed to minimize effects of blood oxygenation and to evaluate blood volume specifically. MATERIALS AND METHODS: Dynamic 3T multi-echo BOLD images of calf muscle were acquired from six healthy volunteers by use of a cuff-compression model. Calculated TE images at TE = 0 ms (cTE0) and T2* map (T2*) were calculated from acquired multi-echo images. The time courses of the mean value for the entire calf muscles in cTE0, in acquired BOLD images at TE = 45.2 ms (aTE45), and in T2* were obtained. The Euclidean distances between the two pairs of time courses were calculated: distance between aTE45 and T2* (D at), and that between cTE0 and T2* (D ct). The difference between D at and D ct was tested by use of the Wilcoxon signed rank test. RESULTS: D at was significantly different from D ct (P = 0.031), indicating that the time course of cTE0 was significantly different from that of blood oxygenation-weighted images (T2* and aTE45). CONCLUSION: The effect of blood oxygenation could be minimized using cTE0. Thus, signal intensity changes of cTE0 reflected changes in blood volume more specifically.
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