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  • Title: Comparison of the Effect of Pre-operative Single Oral Dose of Tramadol and Famotidine on Gastric Secretions pH and Volume in Patients Scheduled for Laparoscopic Cholecystectomy.
    Author: Khan MU, Aqil M, Hussain A, Zahrani TA, Hillis M.
    Journal: J Coll Physicians Surg Pak; 2015 May; 25(5):320-3. PubMed ID: 26008654.
    Abstract:
    OBJECTIVE: To evaluate and compare the effects of pre-operative single oral dose of tramadol and famotidine on gastric secretions pH and volume in patients electively scheduled for laparoscopic cholecystectomy. STUDY DESIGN: Randomized control trial. PLACE AND DURATION OF STUDY: Department of Anaesthesia, King Saud University Riyadh, Saudi Arabia, from August 2011 to June 2013. METHODOLOGY: Ninety adult, ASA-I and II patients scheduled for laparoscopic cholecystectomy were included in the study. Patients were randomly assigned to receive pre-operatively either placebo (Group-C, n=30), oral tramadol 100 mg (Group-T, n=30) or famotidine 40 mg (Group-F, n=30). After induction of general anaesthesia, gastric fluid was aspirated through orogastric tube. The gastric secretions volume and pH was measured using pH meter. RESULTS: There was no statistically difference between groups in age, weight and gender. The gastric secretions mean pH was 2.06 ± 0.22,2.04 ± 0.20, 5.79 ± 0.77 and volume was 0.59 ± 0.17, 0.59 ± 0.14 and 0.28 ± 0.16 ml/kg in Group-C, Group-T and Group-F respectively. There was a significant statistical difference in the mean pH values between Group-C vs. Group-F (p < 0.001) and Group-T vs. Group-F (p < 0.001). Statistically significant difference was also found in the mean gastric secretions volume between Group - C vs. Group-F (p < 0.001) and Group-T vs. Group-F (p < 0.001). There was no significant difference in the mean gastric fluid pH values (p=0.99) and mean gastric secretions volume (p=0.99) between Group-T and Group-C. CONCLUSION: As compared to famotidine, pre-operative single oral dose of tramadol was unable to elevate the desired level of gastric fluid pH (> 2.5) and decrease in gastric secretions volume (< 0.4 ml/kg).
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