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  • Title: Effects of interleukin-6 on the bio-electric activity of rat atrial tissue under normal conditions and during gradual stretching.
    Author: Mitrokhin VM, Mladenov MI, Kamkin AG.
    Journal: Immunobiology; 2015 Sep; 220(9):1107-12. PubMed ID: 26009487.
    Abstract:
    Using the micro-electrode technique we studied the effects of interleukin-6 on bio-electric activity of rat atrial tissue under normal conditions and after gradual stretching. It was shown that IL-6 caused increasing of the duration of the action potential at the levels of 25, 50, and 90% re-polarization. The hump-like depolarization at APD90 appeared 7-10 min after initial stretching and transformed into single extra-potentials after tension removing. Perfusion with IL-6 for more than 20 min led to the appearance of atrial fibrillation even with the application of slight tension. Close observation of the IL-6 induced mechanisms and stretch induced APD alteration, confirmed the existence of a tight link between examined cytokine and stretch induced mechanisms.
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