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  • Title: [Dynamic fractionation of the radiation dosage combined with the local use of metronidazole in bladder cancer].
    Author: Pereslegin IA, Vinogradskiĭ AG, Mufazalov FF.
    Journal: Med Radiol (Mosk); 1989 Dec; 34(12):45-9. PubMed ID: 2601593.
    Abstract:
    The paper is devoted to the description of the combined methods of radiotherapy of urinary bladder cancer and the local use of metronidazole. At the 1st stage of therapy a dose of 140 cGy twice a day with 5-6 h interruption was delivered up to a summary dose of 43 Gy on conversion to small fractionation by the TDF factor. Then two fractions at a single dose of 6 Gy once a week were given. Altogether 36 patients were treated by this method. The control group of patients was given radiation therapy in a split course in the regimen of routine fractionation. Short-term therapeutic results were analyzed for both groups. The total positive effect was higher in the study group (81.25% versus 66.7%). A conclusion is that this method holds promise.
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