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  • Title: Effect of Avastin on the migration and invasion of pterygium fibroblasts.
    Author: Liu W, Sha X, Wen Y, Zhao W, Luo W, Hua Z.
    Journal: Eye Sci; 2014 Dec; 29(4):214-8. PubMed ID: 26016073.
    Abstract:
    PURPOSE: To evaluate the effect of Avastin on human pterygium fibroblast migration and invasiveness. METHODS: VEGF secretion was compared between human pterygium fibroblasts and conjunctival fibroblasts by measuring VEGF-A by ELISA. The influence of Avastin on HPF migration and invasiveness was observed by wound scratch and Transwell migration assays. The expression of p-ERK1/2 and p-FAK was analyzed by western blotting. RESULTS: (1)VEGF was secreted in higher amounts by human pterygium fibroblasts than by conjunctival fibroblasts. (2) Avastin treatment decreased HPF migration and invasion. (3) Avastin significantly decreased the expression of p-ERK1/2 and p-FAK in human pterygium fibroblasts. CONCLUSION: Avastin can inhibit migration and invasion of HPFs by decreasing the expression of p-ERK1/2 and p-FAK.
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