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  • Title: Image features of retinal astrocytic hamartoma in a patient with tuberous sclerosis complex.
    Author: Zhang P, Sun D, Zhu J, Li J, Wang Y.
    Journal: Eye Sci; 2014 Dec; 29(4):223-6. PubMed ID: 26016075.
    Abstract:
    PURPOSE: To describe the image features of retinal astrocytic hamartoma in a 35-year-old male patient with tuberous sclerosis complex (TSC). METHODS: Fundus photography, fundus autofluorescence (FAF), fundus fluorescein angiography (FFA), and spectral domain optical coherence tomography (SD-OCT) were performed for this retinal astrocytic hamartoma. RESULTS: Fundus photography showed that the retinal astrocytic hamartoma presented as a well-circumscribed, mulberry-like lesion consisting of glistening yellowish spherules of calcification. FAF demonstrated dense hyper-autofluorescence spots corresponding to retinal astrocytic hamartoma. FFA revealed leakage from dilated retinal capillaries over the hamartoma. SD-OCT indicated moth-eaten optically empty spaces and hyperreflective dots within the lesion. The lesion surface was fluctuate. CONCLUSION: FAF is a useful imaging modality for obtaining greater contrast between a retinal astrocytic hamartoma and the surrounding retina due to hyper-autofluorescence of calcification in the lesion. FFA is beneficial for monitoring the abnormal blood vessels in these lesions. SD-OCT is capable of visualization the structural details, such as the uneven surface and inner hyperreflective dots.
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