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  • Title: Fatal phenytoin-related toxic epidermal necrolysis: case report.
    Author: Kelly DF, Hope DG.
    Journal: Neurosurgery; 1989 Dec; 25(6):976-8. PubMed ID: 2601830.
    Abstract:
    Toxic epidermal necrolysis is a rare but often fatal hypersensitivity reaction to numerous agents, including most anticonvulsants. The authors present a case of fatal phenytoin-related toxic epidermal necrolysis in a patient who was given prophylactic anticonvulsant therapy after he sustained a moderately severe closed head injury. The typical course and current management of toxic epidermal necrolysis are reviewed, as are the indications for the prophylaxis of posttraumatic epilepsy.
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