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  • Title: Vasopressin-deficient rats show a reduced amplitude of the circadian sleep rhythm.
    Author: Brown MH, Nunez AA.
    Journal: Physiol Behav; 1989 Oct; 46(4):759-62. PubMed ID: 2602503.
    Abstract:
    The hypothalamic suprachiasmatic nuclei are responsible for the generation of many circadian rhythms, including the rhythm of arginine vasopressin (AVP) in the cerebrospinal fluid (CSF). We used cortical EEG recordings taken from AVP-deficient (Brattleboro strain) rats to investigate the possible role of AVP in the generation of circadian sleep/arousal rhythms. When housed either in a light-dark cycle or in constant light, Brattleboro rats showed circadian rhythms of arousal, slow-wave sleep, and paradoxical sleep. However, the amplitudes of the slow-wave and paradoxical sleep (but not arousal) rhythms in these animals were significantly lower than in controls. The results indicate that hypothalamic synthesis of AVP is not necessary for the generation of circadian sleep rhythms, but the amplitude of the rhythms may be modulated by the circadian release of AVP into CSF.
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