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  • Title: Association of Polymorphisms in Innate Immunity Genes TLR9 and DEFB1 with Human Longevity.
    Author: Gankovskaya LV, Svitich OA, Artem'eva OV, Miroshnichenkova AM, Rusanova KV.
    Journal: Bull Exp Biol Med; 2015 May; 159(1):77-80. PubMed ID: 26028230.
    Abstract:
    The distribution of polymorphic variants of innate immunity genes TLR9 (+2848G>A) and DEFB1(-20G>A; -44C>G; -52G>A) was evaluated in long-living individuals. No significant differences were found in the distribution of genotypes and alleles of the TLR9 gene. The following features were revealed: increase in the frequency of AA and GG genotypes and decrease in the frequency of the AG genotype of the DEFB1(-20G>A) gene; increase in the frequency of the CC genotype and C allele and decrease in the frequency of CG and GG genotypes and G allele of the DEFB1(44C>G) gene; and increase in the frequency of AA and AG genotypes and A allele and decrease in the frequency of the GG genotypes and G allele of the DEFB1(-52G>A) gene. Genotypes and alleles of the DEFB1 gene found in long-living individuals can be considered as the factors that increase the probability of longevity and favorable course of age-related diseases.
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