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  • Title: Myasthenia gravis with presynaptic neurophysiological signs: Two case reports and literature review.
    Author: Alboini PE, Damato V, Iorio R, Luigetti M, Evoli A.
    Journal: Neuromuscul Disord; 2015 Aug; 25(8):646-50. PubMed ID: 26028274.
    Abstract:
    The distinction between myasthenia gravis and Lambert-Eaton myasthenic syndrome is based on clinical, neurophysiological and immunological features. We hereby report two cases with a clinical diagnosis of myasthenia gravis and neurophysiological features consistent with a pre-synaptic neuromuscular transmission defect. Both patients had increased anti-acetylcholine receptor antibody titres and showed a good response to cholinesterase inhibitors, along with a >100% facilitation of the compound muscle action potential on electrophysiological studies. We provide a review of English literature studies on co-existing features of myasthenia gravis and Lambert-Eaton myasthenic syndrome, and discuss diagnostic controversies.
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