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  • Title: Proaporphine and aporphine alkaloids with acetylcholinesterase inhibitory activity from Stephania epigaea.
    Author: Dong JW, Cai L, Fang YS, Xiao H, Li ZJ, Ding ZT.
    Journal: Fitoterapia; 2015 Jul; 104():102-7. PubMed ID: 26028544.
    Abstract:
    An unusual proaporphine alkaloid bearing an isopropanenitrile group at isoquinoline nitrogen, named epiganine A (1) and a new aporphine alkaloid, epiganine B (2), together with eight known alkaloids, pronuciferine (3), dehydrodicentrine (4), romerine (5), romeline (6), N-methylcalycinine (7), phanostenine (8), dicentrine (9), and N-methyllaurotetanine (10), were isolated from the roots of Stephania epigaea. The absolute configuration of 1 was determined by calculating electronic circular dichroism (ECD) and comparing with experimental data. Compounds 2 and 4 showed strong acetylcholinesterase (AChE) inhibitory effects with the IC50 values of 4.36 and 2.98μM, respectively. Compounds 5-9 also exhibited potent AChE inhibitory activities.
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