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  • Title: [Gas-chromatographic analysis of hypercholestanol in the bile and its role in the pathogenesis of cholelithiasis].
    Author: Krikshtopaĭtis MI, Chupin SP, Tiuriumin IaL, Nikiforov SB, Fedorova LS, Salenko VL, Vialkov AI.
    Journal: Sov Med; 1989; (9):19-24. PubMed ID: 2603035.
    Abstract:
    The cholestanol/cholesterol ratio in the bladder and liver bile was estimated by capillary gas-liquid chromatography in patients with dyskinesia of the gallbladder, chronic acalculous cholecystitis, and chronic calculous cholecystitis. Cholesterol biliary calculi and their surface and intermediate layers and the core were examined either. The authors came to a conclusion that cholestanol/cholesterol ratio in the bladder and liver bile reflected the progress of liver cholesterol metabolism starting from the early stages of cholelithiasis to the formation of cholesterol biliary calculi. Therefore hypercholestanolcholia should be considered as an indicator of the risk of cholesterol biliary calculi development.
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