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  • Title: A novel approach to the management of a central giant cell granuloma with denosumab: A case report and review of current treatments.
    Author: Gupta B, Stanton N, Coleman H, White C, Singh J.
    Journal: J Craniomaxillofac Surg; 2015 Sep; 43(7):1127-32. PubMed ID: 26032758.
    Abstract:
    PURPOSE: To describe the efficacy of denosumab in the treatment of an aggressive giant cell granuloma of the mandible. METHODS: Denosumab was administered to a patient with a large aggressive giant cell granuloma of the mandible resistant to standard medical therapy. The effectiveness and response was measured on the basis of patient symptoms and radiological parameters. RESULTS: A significant reduction in patient symptoms was reported in association with tumour regression on follow up radiographs. CONCLUSION: This report demonstrates potential use of denosumab in aggressive giant cell granulomas of the jaws that have been resistant to medical therapy.
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