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  • Title: Involvement of PI3K, MAPK ERK1/2 and p38 in Functional Stimulation of Mesenchymal Progenitor Cells by Alkaloid Songorine.
    Author: Zyuz'kov GN, Zhdanov VV, Miroshnichenko LA, Udut EV, Chaikovskii AV, Simanina EV, Danilets MG, Minakova MY, Udut VV, Tolstikova TG, Shults EE, Stavrova LA, Burmina YV, Dygai AM.
    Journal: Bull Exp Biol Med; 2015 May; 159(1):58-61. PubMed ID: 26033591.
    Abstract:
    We studied the role of intracellular signaling molecules PI3K, МАРK ERK1/2, and р38 in stimulation of realization of the growth potential of mesenchymal progenitor cells by alkaloid songorine in vitro. Inhibitors of PI3K, ERK1/2 and р38 canceled the increase in proliferative activity of progenitor cells, the blockers of ERK1/2 and р38 reduced the intensity of progenitor cell differentiation.
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