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  • Title: Intracellularly Degradable, Self-Assembled Amphiphilic Block Copolycurcumin Nanoparticles for Efficient In Vivo Cancer Chemotherapy.
    Author: Lv L, Guo Y, Shen Y, Liu J, Zhang W, Zhou D, Guo S.
    Journal: Adv Healthc Mater; 2015 Jul 15; 4(10):1496-501, 1423. PubMed ID: 26033838.
    Abstract:
    Intracellularly degradable, self-assembled amphiphilic biotin-poly(ethylene glycol)-b-poly(curcumin-dithiodipropionic acid) nanoparticles are developed. They display excellent in vivo anticancer efficacy, benefitted from their high tumor-targeted accumulation and stimuli-triggered intracellular drug release. They can be loaded with other anticancer drugs (e.g., doxorubicin) to exploit the synergy of combinational dual-drug therapy to further enhance in vivo anticancer efficacy.
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