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  • Title: SLFN11: Achilles' Heel or Troublemaker.
    Author: Kovar H.
    Journal: Clin Cancer Res; 2015 Sep 15; 21(18):4033-4. PubMed ID: 26034126.
    Abstract:
    SLFN11 expression correlates with sensitivity of tumors to topoisomerase and DNA-targeting drugs and consequently with prognosis. Regulation of SLFN11 by ETS factors opens new avenues to treatment optimization, maximizing antitumor activity and minimizing adverse side effects. Interrogating drug-induced gene expression signatures for SLFN11 modulations may affect the design of therapeutic regimens.
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