These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Ratio and log odds of positive lymph nodes in breast cancer patients with mastectomy.
    Author: Chen LJ, Chung KP, Chang YJ, Chang YJ.
    Journal: Surg Oncol; 2015 Sep; 24(3):239-47. PubMed ID: 26055316.
    Abstract:
    PURPOSE: This study aimed to investigate the predictive role of lymph nodes (LNs) and assess the prognostic significance of the ratio of positive LNs (LNR) and log odds of positive LNs (LODDS) in breast cancer patients who have undergone a mastectomy. PATIENTS AND METHODS: All of the breast cancer patients in the Taiwan Cancer Database during 2002-2006 were considered. We excluded patients who had inflammatory breast cancer, stage 0 and IV disease, breast conservative surgery or survival <1 month. The primary end point was overall survival (OS). A Cox hazards model was constructed and compared via Nagelkerke R(2) (R(2)N) and receiver operating characteristics (ROC). RESULTS: A total of 11,349 (6042 node-negative, 5307 node-positive) patients were enrolled, and 10.5% patients had a limited number of LNs harvested. In a multivariate Cox model, LNR and LODDS demonstrated prognostic significance (<0.001). For node-positive patients, a model with LNR showed the best fit (P < 0.001; R(2)N = 18.2%) when sufficient LNs were examined. However, a model with LODDS showed the best fit in patients with a limited number of LNs harvested (P < 0.001; R(2)N = 21.1%), even in node-negative patients (P = 0.004; R(2)N = 13.5%). The area under the ROC curve (AUC) was highest for LODDS (AUC: 0.761), followed by LNR (AUC: 0.757). A limited LN harvest induced an AUC value for an approximate 3.6% loss (LNR) or 3.1% loss (LODDS). CONCLUSION: The prognostic superiority of LNR is confounded by a limited LN harvest, thus making LODDS the most powerful and unified prognostic classifier in breast cancer patients who have had a mastectomy.
    [Abstract] [Full Text] [Related] [New Search]