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  • Title: In Vitro Antimalarial Activity of Different Inhibitors of the Plasmodial Isoprenoid Synthesis Pathway.
    Author: da Silva MF, Saito AY, Peres VJ, Oliveira AC, Katzin AM.
    Journal: Antimicrob Agents Chemother; 2015 Aug; 59(8):5084-7. PubMed ID: 26055383.
    Abstract:
    Previous studies have shown that fosmidomycin, risedronate, and nerolidol exert antimalarial activity in vitro. We included squalestatin, an inhibitor of the isoprenoid metabolism in Erwinia uredovora, and found that combinations of compounds which act on different targets of the plasmodial isoprenoid pathway possess important supra-additivity effects.
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