These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
Pubmed for Handhelds
PUBMED FOR HANDHELDS
Search MEDLINE/PubMed
Title: Methimazole-induced agranulocytosis in Japanese patients with Graves' disease. Author: Tamai H, Takaichi Y, Morita T, Komaki G, Matsubayashi S, Kuma K, Walter RM, Kumagai LF, Nagataki S. Journal: Clin Endocrinol (Oxf); 1989 May; 30(5):525-30. PubMed ID: 2605789. Abstract: We reviewed the records of approximately 7000 Japanese patients whose hyperthyroidism was treated with methimazole (MMI) alone. Four patients (Group I) developed agranulocytosis during a second course of MMI therapy and eight patients (Group II) during an initial course. Six patients (three in each group) received less than 30 mg MMI daily. Agranulocytosis occurred after more than 2 months of therapy (12 weeks-1 year) in five patients. Seven patients were less than 40 years of age. One patient displayed a gradual protracted development of agranulocytosis. These results indicate that agranulocytosis after MMI may occur irrespective of dose, age, duration of treatment, and with a second exposure.[Abstract] [Full Text] [Related] [New Search]