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  • Title: Indium-111 WBC scan in acute toxic centrilobular hepatic necrosis.
    Author: Davidson RM, Dhekne RD, Moore WH.
    Journal: Clin Nucl Med; 1989 Dec; 14(12):877-80. PubMed ID: 2605842.
    Abstract:
    In this case of prolonged fever and abnormal liver functions, dual tracer scintigraphy with In-111 WBCs and Tc-99m SC led to a biopsy-proven diagnosis of severe acute toxic hepatitis (hepatocellular necrosis). Correlation of the Tc-99m SC scan findings with those previously reported for "pseudotumors" of the liver is discussed. A "pseudonormal" scan pattern is described for the In-111 WBC scintigraphy. Discordance between In-111 WBC and Tc-99m SC scintigraphy in this clinical setting should raise the possibility of hepatic necrosis as a diagnostic alternative to hepatic abscess.
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