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  • Title: Cross-linking and stereospecific structure of collagen in mineralized and nonmineralized skeletal tissues.
    Author: Yamauchi M, Katz EP, Otsubo K, Teraoka K, Mechanic GL.
    Journal: Connect Tissue Res; 1989; 21(1-4):159-67; discussion 168-9. PubMed ID: 2605940.
    Abstract:
    Molecular distributions of the intermolecular cross-links in fetal bovine bone type I collagen fibrils were quantitatively determined and compared with those of periodontal ligament. Results indicated that Hyl and Lys residues in the COOH-terminal nonhelical peptide portions (residues 16C) of both alpha 1 chains were quantitatively converted to aldehydes. These in turn stoichiometrically formed cross-links with residues Hyl-87 on both alpha 1 and alpha 2 chains of neighboring molecules. The ratio of cross-linked alpha 1 to alpha 2 chains was 3.5 to 1 indicating a stereospecific packing of collagen molecules in the fibrils similar manner to periodontal ligament collagen. It was found that there were few aldehyde derived cross-links in the NH2-terminal nonhelical portions of the bone type I collagen. The relative paucity of the cross-links in NH2-terminal region of bone collagens may favor mineralization.
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