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  • Title: Isolated double pituitary adenomas: A silent corticotroph adenoma and a microprolactinoma.
    Author: Eytan S, Kim KY, Bleich D, Raghuwanshi M, Eloy JA, Liu JK.
    Journal: J Clin Neurosci; 2015 Oct; 22(10):1676-8. PubMed ID: 26067545.
    Abstract:
    We report a 27-year-old woman with amenorrhea and galactorrhea with mildly elevated serum prolactin levels. Her MRI demonstrated a cystic macroadenoma in the left aspect of the sella and a small microadenoma in the right aspect of the sella. Endoscopic transsphenoidal resection of the tumors revealed two histologically distinct tumors. The left tumor was consistent with a silent corticotroph macroadenoma and the right tumor was a prolactin producing microadenoma. Isolated double pituitary adenomas that are clearly separated by normal pituitary gland tissue are extremely rare. The incidence is approximately 0.37-2.6%. The coexistence of double adenomas can pose diagnostic and management challenges for the pituitary neuroendocrine team.
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