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  • Title: A comparison of fluoxetine imipramine and placebo in patients with bipolar depressive disorder.
    Author: Cohn JB, Collins G, Ashbrook E, Wernicke JF.
    Journal: Int Clin Psychopharmacol; 1989 Oct; 4(4):313-22. PubMed ID: 2607128.
    Abstract:
    This was a 6-week, double-blind comparison of fluoxetine, imipramine, and placebo in 89 patients with bipolar depression. Using the criteria of greater than or equal to 50% improvement in the HAMD-total score after at least 3 weeks on study drug, endpoint analysis showed 86% of the fluoxetine-treated patients improved compared with 57% of the imipramine-treated and 38% of the placebo-treated patients. Significantly fewer fluoxetine-treated patients discontinued due to adverse events than did imipramine-treated patients (7% vs. 30%, respectively).
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