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  • Title: A new polyoxygenated cyclohexene and a new megastigmane glycoside from Uvaria grandiflora.
    Author: Ho DV, Kodama T, Le HT, Phan KV, Do TT, Bui TH, Le AT, Win NN, Imagawa H, Ito T, Morita H, Nguyen HT.
    Journal: Bioorg Med Chem Lett; 2015 Aug 15; 25(16):3246-50. PubMed ID: 26077495.
    Abstract:
    A new polyoxygenated cyclohexene, (-)-3-O-debenzoylzeylenone (1), and a new megastigmane glycoside, grandionoside A (2), were isolated from the aerial parts of Uvaria grandiflora collected in Vietnam, together with ten known compounds including polyoxygenated cyclohexenes (3-6), a triterpenoid (7), an alkaloid (8), a long chain alcohol (9), hexenyl glycopyranoside (10), and saponins (11-12). Their chemical structures were elucidated by a combination of extensive NMR spectroscopy with X-ray crystallographic analysis for 1, and chemical conversion for 2. Compound 1 exhibited significant cytotoxicity against the LU-1 and SK-Mel-2 cell lines with IC50 values of 4.68 and 3.63 μM, respectively. Remarkably, the cytotoxicity of 12 against the LU-1, KB, Hep-G2, MKN-7, and SW-480 cell lines was comparable to that of ellipticine, the positive control, with IC50 values ranging from 1.24 to 1.60 μM.
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