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  • Title: Anti-plasmodial activity of bradykinin and analogs.
    Author: Silva AF, Alves FL, Pedron CN, Torres MD, Silva LS, Pinheiro AA, Miranda A, Oliveira VX.
    Journal: Bioorg Med Chem Lett; 2015 Aug 15; 25(16):3311-3. PubMed ID: 26077496.
    Abstract:
    To find effective new candidate antimalarial drugs, bradykinin and its analogs were synthesized and tested for effectiveness against Plasmodium gallinaceum sporozoites and Plasmodium falciparum on erythrocytes. Among them, bradykinin and its P2 analog presented high activity against Plasmodium gallinaceum, but they degrade in plasma. On the other hand, RI-BbKI did not degrade and reached high activity. No analog was active against Plasmodium falciparum.
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