These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Association between the tumor necrosis factor-α-308G/A gene polymorphism and HIV-1 susceptibility: a meta-analysis.
    Author: Jiang C, Li Z, Chen P, Chen L.
    Journal: AIDS Res Hum Retroviruses; 2015 Sep; 31(9):859-65. PubMed ID: 26077837.
    Abstract:
    The tumor necrosis factor-α (TNF-α)-308G/A gene polymorphism influences the pathogenesis and evolution of HIV-1 disease. Many studies have evaluated the association between this polymorphism and HIV-1 susceptibility, but the exact relationship between them remains ambiguous and contradictory. Accordingly, the present study evaluates the exact association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility. A systematic literature search was conducted and the case-control studies that were found assessing the association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility were analyzed. The pooled odds ratios (ORs) and 95% confidence interval (CI) were calculated by a fixed effect model. Heterogeneity was analyzed by Cochran's Q and the I(2) statistics. Publication bias was assessed using the Begg's funnel plot and Egger's test. A total of 679 cases and 873 controls from five studies were included. Overall, no significant relationship was found between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility in this meta-analysis study (A versus G genotype model: OR=0.89, 95% CI=0.59-1.32, p=0.553; GG versus AA+AG model: OR=1.23, 95% CI=0.75-2.02, p=0.407; GG+AG versus AA model: OR=1.40, 95% CI=0.70-2.82, p=0.345; GG versus AA model: OR=1.39, 95% CI=0.69-2.80, p=0.362; AG versus AA model: OR=1.43, 95% CI=0.70-2.96, p=0.329; GG+AA versus AG model: OR=0.76, 95% CI=0.44-1.29, p=0.304). The meta-analysis found no marked association between TNF-α-308G/A gene polymorphism and HIV-1 susceptibility.
    [Abstract] [Full Text] [Related] [New Search]