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  • Title: N-Alkylated aziridines are easily-prepared, potent, specific and cell-permeable covalent inhibitors of human β-glucocerebrosidase.
    Author: Adams BT, Niccoli S, Chowdhury MA, Esarik AN, Lees SJ, Rempel BP, Phenix CP.
    Journal: Chem Commun (Camb); 2015 Jul 21; 51(57):11390-3. PubMed ID: 26085065.
    Abstract:
    β-Glucocerebrosidase deficiency leads to Gaucher disease and is a potential marker of Parkinson's disease. We have identified N-octyl conduritol aziridine as a potent and specific covalent inactivator of GBA1 in living cells. This compound is a promising lead towards a positron emission tomography probe intended to image GBA1 activity.
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