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  • Title: Pneumococcal Waterhouse-Friderichsen syndrome despite a normal spleen.
    Author: Bramley PN, Shah P, Williams DJ, Losowsky MS.
    Journal: Postgrad Med J; 1989 Sep; 65(767):687-8. PubMed ID: 2608604.
    Abstract:
    A previously fit 56 year old female presented with a rapidly progressive and fatal pneumococcal septicaemia with disseminated intravascular coagulation. Post-mortem studies confirmed a Waterhouse-Friderichsen syndrome and revealed an anatomically normal spleen; intracellular diplococci were seen within splenic macrophages providing evidence of normal splenic function. This appears to be only the second case of Waterhouse-Friderichsen syndrome due to pneumococcal septicaemia in a patient with a normal spleen.
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