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  • Title: The Aryne aza-Diels-Alder Reaction: Flexible Syntheses of Isoquinolines.
    Author: Castillo JC, Quiroga J, Abonia R, Rodriguez J, Coquerel Y.
    Journal: Org Lett; 2015 Jul 02; 17(13):3374-7. PubMed ID: 26086988.
    Abstract:
    Two cascade reactions have been developed for the time-efficient preparation of a variety of functionalized aromatic heterocyclic products exhibiting an isoquinoline core. The approach is based on the normal electron-demand [4 + 2] aza-Diels-Alder cycloaddition of electron-rich N-aryl imines with arynes. Using this strategy, an expeditious total synthesis of the naturally occurring benzo[c]phenanthridine alkaloid nornitidine was achieved.
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