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  • Title: Serum miR-26a as a diagnostic and prognostic biomarker in cholangiocarcinoma.
    Author: Wang LJ, Zhang KL, Zhang N, Ma XW, Yan SW, Cao DH, Shi SJ.
    Journal: Oncotarget; 2015 Jul 30; 6(21):18631-40. PubMed ID: 26087181.
    Abstract:
    In order to determine the diagnostic and prognostic value of miR-26a in Cholangiocarcinoma (CCA), we compared miR-26a levels in serum from 66 CCA patients and 66 healthy controls, which was followed by serum analysis between the pre-operative serum and post-operative serum of these CCA patients. We found the concentration levels of miR-26a in serum of CCA patients were significantly higher than that from healthy controls (P < 0.01). Furthermore, the concentration levels of miR-26a in the post-operative serum were significantly reduced when compared to the pre-operative serum (P < 0.001). High miR-26a in serum was correlated significantly with clinical stage, distant metastasis, differentiation status, and poor survival of CCA patients. More importantly, serum miR-26a was an independent prognostic marker for CCA. In conclusion, our results suggested that miR-26a in serum might be a potential and useful noninvasive biomarker for the early detection of CCA.
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