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  • Title: [Effectiveness of radiotherapy of patients with cancer of the cervix uteri at the Central Research Roentgeno-Radiological Institute of the USSR Ministry of Health].
    Author: Kholin VV, Zharinov GM.
    Journal: Vopr Onkol; 1989; 35(12):1476-9. PubMed ID: 2609545.
    Abstract:
    The results of radiation treatment for cervical cancer obtained at the Institute Clinic are discussed. Modification-free irradiation was given to 205 patients. Five-year survival was 94 +/- 4% in stage I, 83 +/- 3%--II and 38 +/- 9% in stage III tumor. Dimethylsulfoxide was administered to prevent radiation injury in 48 patients. Radiation injury to the bladder and rectum was observed in 4.9% of cases for each site whereas in controls the indexes were 6.3 and 13.6%, respectively. In 84 patients, dimethylsulfoxide was used in combination with metronidazole to potentiate radiation damage to tumor. This was followed by a significantly more rapid regression of neoplasms. Two-year survival rate in cases receiving topical treatment with both drugs was 75% while in controls--43%.
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