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  • Title: Two new sesquiterpenoids from cultures of the basidiomycete Tremella foliacea.
    Author: Ding JH, Li ZH, Wei K, Dong ZJ, Ding ZH, Feng T, Liu JK.
    Journal: J Asian Nat Prod Res; 2016; 18(1):46-50. PubMed ID: 26095767.
    Abstract:
    Two new sesquiterpenoids, trefoliol B (1) and trefoliol C (2), together with known echinocidin A (3), were isolated from cultures of the basidiomycetes Tremella foliacea. The new structures were elucidated on the basis of extensive spectroscopic methods. At the same time, trefoliol B (1) and echinocidin A (3) were tested for their cytotoxicities against five human cancer cell lines and for their inhibitory activities against isozymes of 11β-hydroxysteroid dehydrogenases (11β-HSD). No compound showed significant activity (IC50 > 40 μM). Compound 1 showed moderate inhibitory activities against 11β-HSD1 (human IC50 = 13.1 μM; mouse IC50 = 91.8 μM).
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