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  • Title: Combined chemotherapy and photodynamic therapy using a nanohybrid based on layered double hydroxides to conquer cisplatin resistance.
    Author: Wang Z, Ma R, Yan L, Chen X, Zhu G.
    Journal: Chem Commun (Camb); 2015 Jul 25; 51(58):11587-90. PubMed ID: 26096645.
    Abstract:
    A nanohybrid is assembled by ratiometrically co-loading Pt(IV) prodrugs and photosensitizers into layered double hydroxide nanoparticles. The nanohybrid shows synergistic cell-killing effects and is significantly active against the proliferation of cisplatin-resistant human cancer cells with nanomolar IC50 values. Profound mechanistic investigations confirm its action mode of combined chemo- and photodynamic therapy.
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