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  • Title: The Utilities of Chemical Reactions and Molecular Tools for O-GlcNAc Proteomic Studies.
    Author: Kim EJ.
    Journal: Chembiochem; 2015 Jul 06; 16(10):1397-409. PubMed ID: 26096757.
    Abstract:
    The post-translational modification of nuclear and cytoplasmic proteins with O-linked β-N-acetylglucosamine (O-GlcNAc) is involved in a wide variety of cellular processes and is associated with the pathological progression of chronic diseases. Considering its emerging biological significance, systematic identification, site mapping, and quantification of O-GlcNAc proteins are essential and have led to the development of several approaches for O-GlcNAc protein profiling. This minireview mainly focuses on the various useful chemical reactions and molecular tools with detailed reaction mechanisms widely adopted for O-GlcNAc protein/peptide enrichment and its quantification for comprehensive O-GlcNAc protein profiling.
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