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  • Title: Bf and C4 phenotypes in patients with psoriasis.
    Author: Wyatt RJ, Wang C, Hudson EC, Jones RM, Noah PW, Rosenberg EW.
    Journal: Acta Derm Venereol Suppl (Stockh); 1989; 146():211-3. PubMed ID: 2609873.
    Abstract:
    Phenotype frequencies for the complement proteins Bf (factor B), C4A and C4B were performed in a sample of 49 Caucasian patients with psoriasis followed in Memphis, Tennessee. The genes for these proteins are located in the major histocompatibility complex between the HLA-B and HLA-DR loci. Bf phenotype frequency did not differ significantly for the patients as compared to regional controls. The C4*A6 allele was present in 26.6% of the patients as compared to 5.4% of the controls, p less than 0.001, relative risk = 4.93. The C4*A6 allele is known to be in linkage disequilibrium with the HLA B17 allele and produces a functionally defective gene product. The role, if any, of C4*A6 in the pathogenesis of psoriasis is uncertain.
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