These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: By recruiting HDAC1, MORC2 suppresses p21 Waf1/Cip1 in gastric cancer.
    Author: Zhang Q, Song Y, Chen W, Wang X, Miao Z, Cao L, Li F, Wang G.
    Journal: Oncotarget; 2015 Jun 30; 6(18):16461-70. PubMed ID: 26098774.
    Abstract:
    Microrchidia (MORC) family CW-type zinc-finger 2 (MORC2) regulates chromatin remodeling during the DNA-damage response, represses gene transcription, promotes lipogenesis. Here, we found that MORC2 down-regulated p21 by recruiting HDAC1 to the p21 promoter, in a p53-independent manner. MORC2-mediated down-regulation of p21 in turn promoted cell cycle progression in gastric cancer cells. Furthermore, MORC2 expression correlated negatively with p21 expression in gastric tumors in patients. We suggest that MORC2 may be a potential therapeutic target in cancer.
    [Abstract] [Full Text] [Related] [New Search]