These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: [Study of the effect of etoposide on the fluidity of dipalmitoylphosphatidylcholine liposome by differential scanning calorimetry and Raman spectroscopy].
    Author: Liu F, Liao SS.
    Journal: Yao Xue Xue Bao; 1989; 24(5):372-5. PubMed ID: 2609973.
    Abstract:
    The interaction of the anticancer drug, etoposide (VP16-213), with DPPC bilayer vesicles was investigated by DSC and Laser Raman techniques. The results present the fact that the incorporation of VP16-213 into aqueous dispersion of DPPC not only shifted the temperatures of phase transition towards higher value but also broadened the half-height width. The Raman spectra of the DPPC liposome in the C-H symmetric strech vibration lost intensity near 2850cm-1, therefore, it can be predicted that VP16-213 is localized at C1-C9 methylene region of the bilayer, which leads to the increase of the membrane's regularity and the decrease of its fluidity.
    [Abstract] [Full Text] [Related] [New Search]